Lead: University of Birmingham

Work Package 6 (WP6) is the heart of the NanoSolveIT platform, providing a systematic framework for integration of the data and models to generate meaningful hazard and risk assessment predictions. Key features of this work package include optimisation of the sequence in which tools are run, ensuring that the data input and output formats from the different tools are aligned, and optimising the initial input data required to run the models to address different stakeholder questions (safer-by-design, exposure, hazard, risk) and make predictions regarding nanomaterials (NMs) safety, Mode of Action, likelihood of triggering a specific Adverse Outcome Pathway etc. The NMs fingerprint will be the core of the integration, linking laboratory characterization data, computational characteristics, biological signatures and effects.