Toxicogenomics analysis of dynamic dose-response in macrophages highlights molecular alterations relevant for multi-walled carbon nanotube-induced lung fibrosis

Abstract Toxicogenomics approaches are increasingly used to gain mechanistic insight into the toxicity of engineered nanomaterials (ENMs). These emerging technologies have been shown to aid the translation of in vitro experimentation into relevant information on real-life exposures. Furthermore, integrating multiple layers of molecular alteration can provide a broader understanding of the toxicological insult. While there is growing…

NSC Training Day, 23 Nov 2020, NanoSafe Conference

Monday 23 November 2020 In depth training contributions (as proposed) by individual projects For participation in the NanoSafety Cluster Education Day please register here. Room 1Hands-on Training on Nanosafety Tools and ModelsRoom 2NanoSafety Stakeholder engagement, Diplomacy, Regulation and Risk Governance 9:00-9:05 Welcome of the day – Martin Himly (Chair of NSC WG-A) 09:05-10:00 In silico…

NanoSolveIT @ the NanoSafe 2020 Digital Conference

NanoSolveIT participates in the NanoSafe 2020 Digital Conference taking place between 17 – 20 Nov 2020. NanoSolveIT’s oral and poster presentations include: Oral Presentations Lecture Topic 1 – Advanced materials characterization, metrology and standardization Lecture Session 1a – Tue, 17 Nov 2020, Room 1 Papadiamantis et al. – Metadata Stewardship in Nanosafety Research: Significance and…

NanoSolveIT at the NSC Education Day @ NanoSafe 2020 Digital Conference, 16 Nov 2020

The NanoSolveIT project will actively participate in the NSC Education Day satellite event during the NanoSafe Digital Conference 2020. The NanoSolveIT partners will present some of the in silico tools developed by the consortium and collaborating projects like NanoCommons. The sessions that NanoSolveIT participates in: Session 1: New developments in human hazard assessment – focus…

EU NanoSafety Cluster General Assembly, Nov 16, 2020, 13:00-14:30 h CET

EU NanoSafety Cluster (NSC) General Assembly @ NanoSAFE Digital Conference, 16 Nov 2020 The next EU NSC General Assembly will take place during the NanoSafe Digital Conference. Agenda 13:00-13:15 Welcome and Statement from the European Commission (Soren Bowadt) 13:15-13:40 Actions since last meeting 13:40-13:50 Pre-recorded statements from each WG 13:50-14:00 Progress of the Malta Initiative…

NanoSafety Cluster (NSC) Education Day @ NanoSAFE Digital Conference, 16 Nov 2020

NanoSafety Cluster (NSC) Education Day @ NanoSAFE, 16 Nov 2020 Intention: This day shall act as guidance for the entire NanoSafety community, including young researchers, to highlight how individual research projects fit as a puzzle piece into the wider picture. It shall be an orientation-giving and educational event depicting the overall strategy behind NanoSafe(ty). For…

Predicting Cytotoxicity of Metal Oxide Nanoparticles using Isalos Analytics Platform

Abstract A literature curated dataset containing 24 distinct metal oxide (MexOy) nanoparticles (NPs), including 15 physicochemical, structural and assay-related descriptors, was enriched with 62 atomistic computational descriptors and exploited to produce a robust and validated in silico model for prediction of NP cytotoxicity. The model can be used to predict the cytotoxicity (cell viability) of…