Nanoinformatics: Artificial Intelligence and Nanotechnology in the New Decade
PMID: 32189589 DOI: 10.2174/138620732301200316112000
Driving the nanoinformatics wave
The NanoCommons (https://www.nanocommons.eu/) research e-infrastructure and NanoSolveIT (https://nanosolveit.eu/) projects are developing the knowledge management and nanoinformatics tools to support in silico nanosafety assessment (published in Scitech Europa www.scitecheuropa.eu) Afantitis, Antreas, & Lynch, Iseult. (2019). Driving the nanoinformatics wave. https://doi.org/10.5281/zenodo.3765525 To access the publication click here.
EUvsVirus Hackathon
The European Commission, led by the European Innovation Council and in close collaboration with the EU member states, will host a pan-European hackathon to connect civil society, innovators, partners and investors across Europe in order to develop innovative solutions for coronavirus-related challenges. Now is your chance to help tackle coronavirus! When? 24, 25 and 26…
Transcriptomics in Toxicogenomics, Part I: Experimental Design, Technologies, Publicly Available Data, and Regulatory Aspects
Abstract The starting point of successful hazard assessment is the generation of unbiased and trustworthy data. Conventional toxicity testing deals with extensive observations of phenotypic endpoints in vivo and complementing in vitro models. The increasing development of novel materials and chemical compounds dictates the need for a better understanding of the molecular changes occurring in…
Transcriptomics in Toxicogenomics, Part III: Data Modelling for Risk Assessment
Abstract Transcriptomics data are relevant to address a number of challenges in Toxicogenomics (TGx). After careful planning of exposure conditions and data preprocessing, the TGx data can be used in predictive toxicology, where more advanced modelling techniques are applied. The large volume of molecular profiles produced by omics-based technologies allows the development and application of…
Exposure medium and particle ageing moderate the toxicological effects of nanomaterials to Daphnia magna over multiple generations: a case for standard test review?
Abstract Pristine engineered nanomaterials (NMs) entering the aquatic environment become ‘aged’ during their lifetime via chemical, physical and/or biological process. Therefore, traditional ecotoxicology tests which were designed for soluble chemicals prior to the emergence of NMs, use pristine NMs and salt-only media which are not representative of realistic NM exposure scenarios. Exposure medium and NM ageing moderation…
Zeta‐Potential Read‐Across Model Utilizing Nanodescriptors Extracted via the NanoXtract Image Analysis Tool Available on the Enalos Nanoinformatics Cloud Platform
Abstract Zeta potential is one of the most critical properties of nanomaterials (NMs) which provides an estimation of the surface charge, and therefore electrostatic stability in medium and, in practical terms, influences the NM’s tendency to form agglomerates and to interact with cellular membranes. This paper describes a robust and accurate read‐across model to predict…
Mass Cytometry and Single‐Cell RNA‐seq Profiling of the Heterogeneity in Human Peripheral Blood Mononuclear Cells Interacting with Silver Nanoparticles
Abstract Understanding the interactions between nanoparticles (NPs) and human immune cells is necessary for justifying their utilization in consumer products and biomedical applications. However, conventional assays may be insufficient in describing the complexity and heterogeneity of cell–NP interactions. Herein, mass cytometry and single‐cell RNA‐sequencing (scRNA‐seq) are complementarily used to investigate the heterogeneous interactions between silver…
NanoSolveIT Project: Driving nanoinformatics research to develop innovative and integrated tools for in silico nanosafety assessment
Abstract Nanotechnology has enabled the discovery of a multitude of novel materials exhibiting unique physicochemical (PChem) properties compared to their bulk analogues. These properties have led to a rapidly increasing range of commercial applications; this, however, may come at a cost, if an association to long-term health and environmental risks is discovered or even just…
JRC Workshop on Safe and Sustainable Smart Nanomaterials
The European Commission’s Joint Research Centre (JRC) and the Directorate-General for Research and Innovation (RTD) will jointly organise a Workshop on Safe and Sustainable Smart Nanomaterials in Ispra (Italy) on 24-25 March 2020. The workshop is focused on smart (responsive, multi-functional) nanomaterials, as such or embedded in products, which are developed for application in industrial sectors such…